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| Cat.No | ACP10962 | Target Name | TBC1D17 |
|---|---|---|---|
| Target Synonyms | TBC1 domain family member 17; TBC17_HUMAN; Tbc1d17 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-648 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9HA65 |
|---|
Uniprot Id
Q9HA65
Target Species
Human
Target Name
TBC1D17
Target Full Name
TBC1 domain family member 17
Target Function
Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known.
Target Subcellular Location
Cytoplasmic vesicle, autophagosome.
Target Synonyms
TBC1 domain family member 17; TBC17_HUMAN; Tbc1d17
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