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| Cat.No | ACP12315 | Target Name | TBC1D2 |
|---|---|---|---|
| Target Synonyms | TBC1D2; PARIS1; PP8997; TBC1D2A; TBC1 domain family member 2A; Armus; Prostate antigen recognized and identified by SEREX 1; PARIS-1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BYX2 |
|---|
Uniprot Id
Q9BYX2
Target Species
Human
Target Name
TBC1D2
Target Full Name
TBC1 domain family member 2A
Target Function
Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.
Target Subcellular Location
Cytoplasm. Cytoplasmic vesicle. Cell junction.
Target Tissue Specificity
Expressed in a broad range of tissues, especially in kidney, liver, lung and placenta. Also expressed in keratinocytes and epithelia-containing organs. Isoform 2 is differentially expressed in prostate normal and cancer cells (at protein level).
Target Synonyms
TBC1D2; PARIS1; PP8997; TBC1D2A; TBC1 domain family member 2A; Armus; Prostate antigen recognized and identified by SEREX 1; PARIS-1
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