Recombinant Human Telomerase-binding protein EST1A (SMG6), Truncated

Uniprot Id

Q86US8

Target Species

Human

Target Name

SMG6

Target Full Name

Telomerase-binding protein EST1A

Target Function

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER).; Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA.

Target Subcellular Location

Nucleus, nucleolus. Chromosome, telomere. Cytoplasm, cytosol. Note=Particularly enriched in the nucleolus.

Target Tissue Specificity

Ubiquitous.

Target Research Area

Cancer

Target Synonyms

SMG6; C17orf31; EST1A; KIAA0732Telomerase-binding protein EST1A; EC 3.1.-.-; EST1-like protein A; Ever shorter telomeres 1A; Smg-6 homolog; Telomerase subunit EST1A; hSmg5/7a

Target Background

This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described.