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The production of recombinant Human TNXB protein involves manipulating the expression of the desired gene in e.coli cells. The sequence (1-673aa) of foreign DNA is merged with an expression vector and subsequently introduced into e.coli cells. Positive cells are chosen and cultivated to induce the expression of the desired protein. A N-terminal 10xHis tag and C-terminal Myc tag is fused to the protein. The resulting recombinant Human TNXB protein undergoes purification through affinity purification, with a purity exceeding 85%, as confirmed by SDS-PAGE.
The production of recombinant Human TNXB protein involves manipulating the expression of the desired gene in e.coli cells. The sequence (1-673aa) of foreign DNA is merged with an expression vector and subsequently introduced into e.coli cells. Positive cells are chosen and cultivated to induce the expression of the desired protein. A N-terminal 10xHis tag and C-terminal Myc tag is fused to the protein. The resulting recombinant Human TNXB protein undergoes purification through affinity purification, with a purity exceeding 85%, as confirmed by SDS-PAGE.
| Cat.No | ACP01042 | Target Name | TNXB |
|---|---|---|---|
| Target Synonyms | (TN-X)(Hexabrachion-like protein) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-673aa |
| Mol Weight | 81.5 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P22105 |
|---|
Uniprot Id
P22105
Target Species
Human
Target Name
TNXB
Target Full Name
Tenascin-X
Target Function
Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.
Target Involvement
Ehlers-Danlos syndrome due to tenascin X deficiency (EDSTNXD); Vesicoureteral reflux 8 (VUR8)
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Protein Families
Tenascin family
Target Tissue Specificity
Highly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB-short is only expressed in the adrenal gland.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
EDS3; Ehlers Danlos like syndrome; Growth inhibiting protein 45; Hexabrachion like protein; Hexabrachion-like protein; HXBL; NXB2; Tenascin X; Tenascin X precursor; Tenascin XB; Tenascin XB1; Tenascin XB2; Tenascin-X; TENX; TENX_HUMAN; TN X; TN-X; TNX; TNXB; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS
Target Background
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene.
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