Recombinant Human Tetratricopeptide repeat protein 35 (TTC35)

Uniprot Id

Q15006

Target Species

Human

Target Name

EMC2

Target Full Name

ER membrane protein complex subunit 2

Target Function

Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)

Target Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

EMC2 family

Target Synonyms

EMC2; KIAA0103; TTC35ER membrane protein complex subunit 2; Tetratricopeptide repeat protein 35; TPR repeat protein 35