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The expression region of this recombinant Human TAB2 covers amino acids 401-693. This TAB2 protein is theoretically predicted to have a molecular weight of 37.1 kDa. The TAB2 protein was expressed in baculovirus. The N-terminal 10xHis tag and C-terminal Myc tag was fused into the coding gene segment of TAB2, making it easier to detect and purify the TAB2 recombinant protein in the later stages of expression and purification.TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) is a protein of significant research interest. Its studies focus on signal transduction and immune regulation. TAB2 plays a crucial role in the TGF-beta signaling pathway, regulating cellular processes such as proliferation, differentiation, and apoptosis. In the area of immune regulation, TAB2 is involved in modulating inflammatory responses and immune cell functions. Recent studies suggest a potential association of TAB2 with the onset and progression of tumors. This positions TAB2 as a key molecule in research areas such as immunology, cancer, and signal transduction.
The expression region of this recombinant Human TAB2 covers amino acids 401-693. This TAB2 protein is theoretically predicted to have a molecular weight of 37.1 kDa. The TAB2 protein was expressed in baculovirus. The N-terminal 10xHis tag and C-terminal Myc tag was fused into the coding gene segment of TAB2, making it easier to detect and purify the TAB2 recombinant protein in the later stages of expression and purification.TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) is a protein of significant research interest. Its studies focus on signal transduction and immune regulation. TAB2 plays a crucial role in the TGF-beta signaling pathway, regulating cellular processes such as proliferation, differentiation, and apoptosis. In the area of immune regulation, TAB2 is involved in modulating inflammatory responses and immune cell functions. Recent studies suggest a potential association of TAB2 with the onset and progression of tumors. This positions TAB2 as a key molecule in research areas such as immunology, cancer, and signal transduction.
| Cat.No | ACP03201 | Target Name | TAB2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Baculovirus |
| Expression Range | 401-693aa | Mol Weight | 37.1 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NYJ8 |
|---|
Uniprot Id
Q9NYJ8
Target Species
Human
Target Name
TAB2
Target Full Name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Target Function
Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development.
Target Involvement
Congenital heart defects, multiple types, 2 (CHTD2)
Target Subcellular Location
Membrane; Peripheral membrane protein. Cytoplasm, cytosol.
Target Tissue Specificity
Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
Target Research Area
Immunology
Target Synonyms
CHTD2; FLJ21885; KIAA0733; MAP3K7IP2; Mitogen activated protein kinase kinase kinase 7 interacting protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; OTTHUMP00000040125; TAB 2; TAB-2; Tab2; TAB2_HUMAN; TAK1 binding protein 2; TAK1-binding protein 2; TGF beta activated kinase 1/MAP3K7 binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2
Target Background
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants.
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