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Amino acids 37-524 constitute the expression domain of recombinant Human TXNRD2. The expected molecular weight for the TXNRD2 protein is calculated to be 68.9 kDa. This TXNRD2 recombinant protein is manufactured in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of TXNRD2, making it easier to detect and purify the TXNRD2 recombinant protein in the later stages of expression and purification.The human thioredoxin reductase 2, mitochondrial (TXNRD2) is an enzyme primarily localized in the mitochondria. TXNRD2 plays a crucial role in cellular redox homeostasis by catalyzing the reduction of thioredoxin, a key regulator of cellular redox status. This process is essential for maintaining the proper function of various cellular proteins and protecting cells from oxidative damage. Additionally, TXNRD2 contributes to the regulation of apoptosis and participates in DNA synthesis. Dysregulation of TXNRD2 has been implicated in various diseases, including cancer and neurodegenerative disorders. Research on TXNRD2 focuses on understanding its functions in cellular redox signaling, its role in health and disease, and its potential as a therapeutic target.
Amino acids 37-524 constitute the expression domain of recombinant Human TXNRD2. The expected molecular weight for the TXNRD2 protein is calculated to be 68.9 kDa. This TXNRD2 recombinant protein is manufactured in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of TXNRD2, making it easier to detect and purify the TXNRD2 recombinant protein in the later stages of expression and purification.The human thioredoxin reductase 2, mitochondrial (TXNRD2) is an enzyme primarily localized in the mitochondria. TXNRD2 plays a crucial role in cellular redox homeostasis by catalyzing the reduction of thioredoxin, a key regulator of cellular redox status. This process is essential for maintaining the proper function of various cellular proteins and protecting cells from oxidative damage. Additionally, TXNRD2 contributes to the regulation of apoptosis and participates in DNA synthesis. Dysregulation of TXNRD2 has been implicated in various diseases, including cancer and neurodegenerative disorders. Research on TXNRD2 focuses on understanding its functions in cellular redox signaling, its role in health and disease, and its potential as a therapeutic target.
| Cat.No | ACP04314 | Target Name | TXNRD2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 37-524aa(U523S) | Mol Weight | 68.9kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NNW7 |
|---|
Uniprot Id
Q9NNW7
Target Species
Human
Target Name
TXNRD2
Target Full Name
Thioredoxin reductase 2, mitochondrial
Target Function
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.
Target Subcellular Location
Mitochondrion.
Target Protein Families
Class-I pyridine nucleotide-disulfide oxidoreductase family
Target Tissue Specificity
Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608
Target Research Area
Others
Target Synonyms
mitochondrial; Selenoprotein Z; SelZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; Thioredoxin reductase 3; Thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TR3; TRXR 2; TRXR2; TRXR2_HUMAN; TXNRD 2; Txnrd2
Target Background
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene.
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