Recombinant Human Thioredoxin-related transmembrane protein 1 (TMX1), Truncated

Uniprot Id

Q9H3N1

Target Species

Human

Target Name

TMX1

Target Full Name

Thioredoxin-related transmembrane protein 1

Target Function

May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.

Target Subcellular Location

Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Ubiquitous. Highly expressed in kidney, liver, placenta and lung.

Target Synonyms

PDIA11; Protein disulfide isomerase family A, member 11; Thioredoxin domain containing 1; Thioredoxin domain containing; Thioredoxin domain-containing protein 1; Thioredoxin-related transmembrane protein 1; TMX; TMX1; TMX1_HUMAN; Transmembrane Trx-related protein; TXNDC; TXNDC1

Target Background

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides.