Recombinant Human Thrombomodulin (THBD), Truncated

Uniprot Id

P07204

Target Species

Human

Target Name

THBD

Target Full Name

Thrombomodulin

Target Function

Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

Target Involvement

Thrombophilia due to thrombomodulin defect (THPH12); Hemolytic uremic syndrome atypical 6 (AHUS6)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Endothelial cells are unique in synthesizing thrombomodulin.

Target Research Area

Cardiovascular

Target Synonyms

THBD; THRM; Thrombomodulin; TM; Fetomodulin; CD antigen CD141

Target Background

The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.