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The production of this Recombinant Human THBS1 protein started with the THBS1 gene synthesis. And then using recombinant DNA technology, the THBS1 gene was inserted into an expression vector so that we could get the recombinant express plasmid of THBS1. Transform the plasmid into the cells of E.coli, culture the cells and we could get the desired Recombinant Human THBS1 protein. But the work was not completed, protein purification and a strict QC system were performed in the last step. The purity is 90%+ determined by SDS-PAGE.THBS1 (also named TSP or TSP1) is a gene providing an instruction of making a protein named thrombospondin-1 (abbreviated as THBS1) in human. THBS1 protein is also called glycoprotein G and is a subunit of a disulfide-linked homotrimeric protein. This protein is well known as a natural angiogenesis inhibitor and has a potent effect on tumor growth of the ability to inhibit angiogenesis. The anti-angiogenic effect of thrombospondin-1 is mediated by inhibiting vascular endothelial cell adhesion and migration.
The production of this Recombinant Human THBS1 protein started with the THBS1 gene synthesis. And then using recombinant DNA technology, the THBS1 gene was inserted into an expression vector so that we could get the recombinant express plasmid of THBS1. Transform the plasmid into the cells of E.coli, culture the cells and we could get the desired Recombinant Human THBS1 protein. But the work was not completed, protein purification and a strict QC system were performed in the last step. The purity is 90%+ determined by SDS-PAGE.THBS1 (also named TSP or TSP1) is a gene providing an instruction of making a protein named thrombospondin-1 (abbreviated as THBS1) in human. THBS1 protein is also called glycoprotein G and is a subunit of a disulfide-linked homotrimeric protein. This protein is well known as a natural angiogenesis inhibitor and has a potent effect on tumor growth of the ability to inhibit angiogenesis. The anti-angiogenic effect of thrombospondin-1 is mediated by inhibiting vascular endothelial cell adhesion and migration.
| Cat.No | ACP02289 | Target Name | THBS1 |
|---|---|---|---|
| Target Synonyms | THBS 1; THBS; Thbs1; Thrombospondin 1; Thrombospondin-1; TSP 1; TSP; TSP1; TSP1_HUMAN | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 19-344aa |
| Mol Weight | 40.6kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P07996 |
|---|
Uniprot Id
P07996
Target Species
Human
Target Name
THBS1
Target Full Name
Thrombospondin-1
Target Function
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors.
Target Subcellular Location
Secreted. Cell surface. Secreted, extracellular space, extracellular matrix. Endoplasmic reticulum. Sarcoplasmic reticulum.
Target Protein Families
Thrombospondin family
Target Research Area
Cell Adhesion
Target Synonyms
THBS 1; THBS; Thbs1; Thrombospondin 1; Thrombospondin-1; TSP 1; TSP; TSP1; TSP1_HUMAN
Target Background
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
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