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| Cat.No | ACP03470 | Target Name | TK2 |
|---|---|---|---|
| Target Synonyms | EC 2.7.1.21; KITM_HUMAN; mitochondrial; Mt TK ; Mt-TK; Thymidine kinase 2; Thymidine kinase 2 mitochondrial ; TK2 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 34-265aa |
| Mol Weight | 32.5 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O00142 |
|---|
Uniprot Id
O00142
Target Species
Human
Target Name
TK2
Target Full Name
Thymidine kinase 2, mitochondrial
Target Function
Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents.
Target Involvement
Mitochondrial DNA depletion syndrome 2 (MTDPS2); Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 3 (PEOB3)
Target Subcellular Location
Mitochondrion.
Target Protein Families
DCK/DGK family
Target Tissue Specificity
Predominantly expressed in liver, pancreas, muscle, and brain.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
EC 2.7.1.21; KITM_HUMAN; mitochondrial; Mt TK ; Mt-TK; Thymidine kinase 2; Thymidine kinase 2 mitochondrial ; TK2
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