Recombinant Human Thyroglobulin (TG), Truncated

Uniprot Id

P01266

Target Species

Human

Target Name

TG

Target Full Name

Thyroglobulin

Target Function

Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules.

Target Involvement

Thyroid dyshormonogenesis 3 (TDH3); Autoimmune thyroid disease 3 (AITD3)

Target Subcellular Location

Secreted.

Target Protein Families

Type-B carboxylesterase/lipase family

Target Tissue Specificity

Specifically expressed in the thyroid gland.

Target Research Area

Others

Target Synonyms

Tg

Target Background

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.