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The recombinant Human THRA protein is produced by constructing the recombinant plasmid encoding the Human THRA protein (1-490aa), transforming recombinant plasmid into e.coli cells, screening the positive e.coli cells and culturing them, and inducing the protein expression. The protein is equipped with a N-terminal 6xHis tag. Following expression, the recombinant THRA protein is isolated and purified from the cell lysate using affinity purification. Denaturing SDS-PAGE is then employed to resolve the resulting recombinant Human THRA protein. Its purity is greater than 85%.
The recombinant Human THRA protein is produced by constructing the recombinant plasmid encoding the Human THRA protein (1-490aa), transforming recombinant plasmid into e.coli cells, screening the positive e.coli cells and culturing them, and inducing the protein expression. The protein is equipped with a N-terminal 6xHis tag. Following expression, the recombinant THRA protein is isolated and purified from the cell lysate using affinity purification. Denaturing SDS-PAGE is then employed to resolve the resulting recombinant Human THRA protein. Its purity is greater than 85%.
| Cat.No | ACP05187 | Target Name | THRA |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-490aa | Mol Weight | 58.9 kDa |
| Protein Length | Full length | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P10827 |
|---|
Uniprot Id
P10827
Target Species
Human
Target Name
THRA
Target Full Name
Thyroid hormone receptor alpha
Target Function
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.; Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
Target Involvement
Hypothyroidism, congenital, non-goitrous, 6 (CHNG6)
Target Subcellular Location
Nucleus.; [Isoform Alpha-2]: Cytoplasm. Nucleus.
Target Protein Families
Nuclear hormone receptor family, NR1 subfamily
Target Research Area
Neuroscience
Target Synonyms
c-erbA-1; C-erbA-alpha; EAR-7; ERBA 1; ERBA; ERBA related 7; Nuclear receptor subfamily 1 group A member 1; THA_HUMAN; THRA; Thra1; Thra2; Thyroid hormone receptor alpha 1; Thyroid hormone receptor alpha 2; Thyroid hormone receptor alpha; TR alpha 1; TR alpha 2; Tra1; Triiodothyronine receptor; V-erbA-related protein 7
Target Background
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
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