Recombinant Human Thyroid hormone receptor alpha (THRA)

Uniprot Id

P10827

Target Species

Human

Target Name

THRA

Target Full Name

Thyroid hormone receptor alpha

Target Function

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.; Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.

Target Involvement

Hypothyroidism, congenital, non-goitrous, 6 (CHNG6)

Target Subcellular Location

Nucleus.; [Isoform Alpha-2]: Cytoplasm. Nucleus.

Target Protein Families

Nuclear hormone receptor family, NR1 subfamily

Target Research Area

Neuroscience

Target Synonyms

c-erbA-1; C-erbA-alpha; EAR-7; ERBA 1; ERBA; ERBA related 7; Nuclear receptor subfamily 1 group A member 1; THA_HUMAN; THRA; Thra1; Thra2; Thyroid hormone receptor alpha 1; Thyroid hormone receptor alpha 2; Thyroid hormone receptor alpha; TR alpha 1; TR alpha 2; Tra1; Triiodothyronine receptor; V-erbA-related protein 7

Target Background

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.