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Recombinant Human TM2 domain-containing protein 1 (TM2D1), Truncated

ACP07191

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Specifications

Cat.No	ACP07191	Target Name	TM2D1
Target Synonyms	TM2D1; BBP; TM2 domain-containing protein 1; Amyloid-beta-binding protein; hBBP	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9BX74

Background Information

Uniprot Id

Q9BX74
Target Species

Human
Target Name

TM2D1
Target Full Name

TM2 domain-containing protein 1
Target Function

May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42.
Target Subcellular Location

Membrane; Multi-pass membrane protein.
Target Protein Families

TM2 family
Target Tissue Specificity

Widely expressed.
Target Synonyms

TM2D1; BBP; TM2 domain-containing protein 1; Amyloid-beta-binding protein; hBBP
Target Background

The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene.

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Recombinant Human TM2 domain-containing protein 1 (TM2D1), Truncated

Specifications

Immunogen Information

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