Recombinant Human Toll-like receptor 2 (TLR2), Truncated

The recombinant Human TLR2 protein is encoded by the gene of TLR2 (19-588aa). The gene of TLR2 was cloned in a system (E.coli) that supported the expression of TLR2. Modification of TLR2 by recombinant DNA technology could lead to the expression of the target protein. The protein was fused with N-terminal 6xHis-SUMO tag in the production. The purity is 90% determined by SDS-PAGE.TLR2 is a protein coding gene that encodes Toll-like receptor 2. According to some research, TLR2 may have the following features. TLR2 and TLR4 have different roles in recognizing the cell wall components of Gram-negative and Gram-positive bacteria. The crystal structure of TLR1-TLR2 heterodimer induced by triacylated lipopeptide. Toll-like receptor 2 (TLR2) and TLR4 activate human dendritic cells to varying degrees. Kidney-related TLR2 mediates renal ischemia/reperfusion injury. TLR9 regulates Th1 response and cooperates with TLR2 to mediate the best resistance to Mycobacterium tuberculosis. TLR2 is expressed on activated T cells and is a cost-stimulating receptor. Factors produced by cancer cells activate bone marrow cells through TLR2 to stimulate metastasis. TIRAP plays an important role in activating the signal cascade shared by TLR2 and TLR4.

ACP04184

Number

Cat.No	ACP04184	Target Name	TLR2
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	19-588aa	Mol Weight	80.4kDa
Protein Length	Partial	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04184

Target Name

TLR2

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

19-588aa

Mol Weight

80.4kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O60603

Background Information

Uniprot Id

O60603
Target Species

Human
Target Name

TLR2
Target Full Name

Toll-like receptor 2
Target Function

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4. MAPK activation in response to bacterial peptidoglycan also occurs via this receptor. Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen. M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression. Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides. Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM.
Target Subcellular Location

Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft.
Target Protein Families

Toll-like receptor family
Target Tissue Specificity

Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
Target Research Area

Immunology
Target Synonyms

CD282; CD282 antigen; TIL 4; TIL4; TLR 2; TLR2; TLR2_HUMAN; Toll like receptor 2; Toll like receptor 2 precursor; Toll-like receptor 2; Toll/interleukin 1 receptor like 4; Toll/interleukin 1 receptor like protein 4; Toll/interleukin receptor like protein 4; Toll/interleukin-1 receptor-like protein 4
Target Background

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.

Recombinant Human Toll-like receptor 2 (TLR2), Truncated

Specifications

Immunogen Information

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