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| Cat.No | ACP01595 | Target Name | TCN2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-200aa | Mol Weight | 54.0 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P20062 |
|---|
Uniprot Id
P20062
Target Species
Human
Target Name
TCN2
Target Full Name
Transcobalamin-2
Target Function
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Target Involvement
Transcobalamin II deficiency (TCN2 deficiency)
Target Subcellular Location
Secreted.
Target Protein Families
Eukaryotic cobalamin transport proteins family
Target Research Area
Cardiovascular
Target Synonyms
D22S676; D22S750; II; Macrocytic anemia; OTTHUMP00000199117; OTTHUMP00000199118; OTTHUMP00000199119; TC; TC II; TC II deficiency; TC-2; TC2; TCII; TCN2; TCN2 deficiency; TCO2_HUMAN; Transcobalamin 2; Transcobalamin 2 deficiency; Transcobalamin II; Transcobalamin II; macrocytic anemia; Transcobalamin-2; Vitamin B12 binding protein 2
Target Background
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.
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