Recombinant Human Transcription factor COE3 (EBF3)

Uniprot Id

Q9H4W6

Target Species

Human

Target Name

EBF3

Target Full Name

Transcription factor COE3

Target Function

Transcriptional activator. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.

Target Involvement

Hypotonia, ataxia, and delayed development syndrome (HADDS)

Target Subcellular Location

Nucleus.

Target Protein Families

COE family

Target Tissue Specificity

Expressed in brain.

Target Synonyms

COE 3; COE3; COE3_HUMAN; Early B cell factor 3; Early B-cell factor 3; EBF 3; EBF-3; EBF3; O/E 2; O/E-2; O/E2; OE 2; OE-2; OE2; Olf 1/EBF like 2; Olf-1/EBF-like 2; Transcription factor COE3

Target Background

This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma.