Recombinant Human Transcription factor IIIB 50 kDa subunit (BRF2)

Uniprot Id

Q9HAW0

Target Species

Human

Target Name

BRF2

Target Full Name

Transcription factor IIIB 50 kDa subunit

Target Function

General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress.

Target Subcellular Location

Nucleus.

Target Protein Families

TFIIB family

Target Synonyms

B-related factor 2; BRF-2; BRF2; BRF2_HUMAN; BRFU; FLJ11052; hBRFU; hTFIIIB50; RNA polymerase III transcription initiation factor BRF2; TFIIIB50; Transcription factor IIB- related factor TFIIIB50; Transcription factor IIIB 50 kDa subunit

Target Background

This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein.