Recombinant Human Transcription factor NF-E2 45 kDa subunit (NFE2)

Uniprot Id

Q16621

Target Species

Human

Target Name

NFE2

Target Full Name

Transcription factor NF-E2 45 kDa subunit

Target Function

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.

Target Subcellular Location

Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.

Target Protein Families

BZIP family, CNC subfamily

Target Tissue Specificity

Expressed in hematopoietic cells and also in colon and testis.

Target Synonyms

erythroid-derived 2 45 kDa subunit; Leucine zipper protein NF-E2; Leucine zipper protein NFE2; NF E2; nfe2; NFE2_HUMAN; Nuclear factor (erythroid derived 2); 45kDa; nuclear factor (erythroid-derived 2); 45kD; Nuclear factor; nuclear factor; erythroid 2; Nuclear factor; erythroid derived 2 45 kDa subunit; p45; p45 NF-E2; p45 NFE2; Transcription factor NF-E2 45 kDa subunit; Transcription factor NFE2 45 kDa subunit