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To produce recombinant Human SOX2 protein, a well-established recombinant DNA technology is the key. A DNA template of SOX2 was constructed with N-terminal 6xHis-SUMO tag using the technique. Once the template was made, the recombinant Human SOX2 protein could be produced with it efficiently. CUSABIO has built a strict QC system to ensure quality. The expression region is 1-317aa of the Human SOX2. The purity of this recombinant is 85% determined by SDS-PAGE. SOX2 is a protein coding gene that encodes Transcription factor SOX-2. According to some studies, SOX2 may have the following features.The basic function of Sox2 is to stabilize ES cells in a pluripotent state by maintaining the necessary expression levels of Oct3/4. Oct4 and Sox2 bind to the Nanog promoter in live mouse and human embryonic stem cells. Pluripotent cell lines in early mouse development depend on SOX2 function. Constitutive expression of SOX2 inhibits neuronal differentiation and leads to the maintenance of primary characteristics. SOX2 controls tumorigenesis and cancer stem cell function in squamous cell carcinoma. SOX2 is an amplified linear survival oncogene in lung and esophageal squamous cell carcinoma.
To produce recombinant Human SOX2 protein, a well-established recombinant DNA technology is the key. A DNA template of SOX2 was constructed with N-terminal 6xHis-SUMO tag using the technique. Once the template was made, the recombinant Human SOX2 protein could be produced with it efficiently. CUSABIO has built a strict QC system to ensure quality. The expression region is 1-317aa of the Human SOX2. The purity of this recombinant is 85% determined by SDS-PAGE. SOX2 is a protein coding gene that encodes Transcription factor SOX-2. According to some studies, SOX2 may have the following features.The basic function of Sox2 is to stabilize ES cells in a pluripotent state by maintaining the necessary expression levels of Oct3/4. Oct4 and Sox2 bind to the Nanog promoter in live mouse and human embryonic stem cells. Pluripotent cell lines in early mouse development depend on SOX2 function. Constitutive expression of SOX2 inhibits neuronal differentiation and leads to the maintenance of primary characteristics. SOX2 controls tumorigenesis and cancer stem cell function in squamous cell carcinoma. SOX2 is an amplified linear survival oncogene in lung and esophageal squamous cell carcinoma.
| Cat.No | ACP04203 | Target Name | SOX2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-317aa | Mol Weight | 50.3kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P48431 |
|---|
Uniprot Id
P48431
Target Species
Human
Target Name
SOX2
Target Full Name
Transcription factor SOX-2
Target Function
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.
Target Involvement
Microphthalmia, syndromic, 3 (MCOPS3)
Target Subcellular Location
Nucleus.
Target Research Area
Transcription
Target Synonyms
ANOP3; cb236; Delta EF2a; lcc; MCOPS3; MGC148683; MGC2413; RGD1565646; Sex determining region Y box 2; SOX 2; Sox2; SOX2_HUMAN; SRY (sex determining region Y) box 2; SRY box containing gene 2; SRY related HMG box 2; SRY related HMG box gene 2; SRY-box 2; Transcription factor SOX 2; Transcription factor SOX-2; ysb
Target Background
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
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