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| Cat.No | ACP04267 | Target Name | GTF2E2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-291aa | Mol Weight | 37.0kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P29084 |
|---|
Uniprot Id
P29084
Target Species
Human
Target Name
GTF2E2
Target Full Name
Transcription initiation factor IIE subunit beta
Target Function
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Target Involvement
Trichothiodystrophy 6, non-photosensitive (TTD6)
Target Subcellular Location
Nucleus.
Target Protein Families
TFIIE beta subunit family
Target Research Area
Transcription
Target Synonyms
FE; General transcription factor IIE subunit 2; General transcription factor IIE; polypeptide 2; beta 34kDa ; gtf2e2; T2EB_HUMAN; TF2E 2; TF2E2; TFIIE B; TFIIE-beta; Transcription initiation factor IIE beta subunit; Transcription initiation factor IIE subunit beta
Target Background
The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE.
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