Recombinant Human Transcription initiation factor TFIID subunit 3 (TAF3), Truncated

Uniprot Id

Q5VWG9

Target Species

Human

Target Name

TAF3

Target Full Name

Transcription initiation factor TFIID subunit 3

Target Function

Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.

Target Subcellular Location

Nucleus.

Target Protein Families

TAF3 family

Target Synonyms

140 kDa TATA box-binding protein-associated factor; Bip2 protein; RNA polymerase II transcription factor TAFII140; TAF(II)140; TAF140; TAF3; TAF3 RNA polymerase II TATA box binding protein (TBP)-associated factor; TAF3_HUMAN; TAFII-140; TAFII140; TAFII155 protein ; TATA box binding protein associated factor 3; TBP-associated factor 3; Transcription initiation factor TFIID 140 kDa subunit; Transcription initiation factor TFIID subunit 3

Target Background

The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).