Recombinant Human Transcriptional activator protein Pur-alpha (PURA)

Uniprot Id

Q00577

Target Species

Human

Target Name

PURA

Target Full Name

Transcriptional activator protein Pur-alpha

Target Function

This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.

Target Involvement

Mental retardation, autosomal dominant 31 (MRD31)

Target Subcellular Location

Nucleus.

Target Protein Families

PUR DNA-binding protein family

Target Synonyms

PUR ALPHA; PUR1; purA; PURA_HUMAN; PURALPHA; Purine rich element binding protein A; Purine rich single stranded DNA binding protein alpha; Purine-rich single-stranded DNA-binding protein alpha; Transcriptional activator protein PUR alpha; Transcriptional activator protein Pur-alpha

Target Background

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.