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The recombinant Human TEAD2 was expressed with the amino acid range of 94-447. This TEAD2 protein is expected to have a theoretical molecular weight of 47.0 kDa. This protein is generated in a e.coli-based system. The TEAD2 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant TEAD2 protein in following stages of expression and purification.The human transcriptional enhancer factor TEF-4, also known as TEAD2, is a member of the TEAD family of transcription factors. TEAD2 plays a crucial role in the regulation of gene expression by binding to the MCAT element (Muscle CAT box), a common cis-regulatory element found in muscle-specific genes. TEAD2 is involved in various biological processes, including embryonic development, cell proliferation, and tissue homeostasis. It acts as a transcriptional coactivator and interacts with different transcription factors, such as Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), forming complexes that modulate gene expression. TEAD2's involvement in the Hippo signaling pathway underscores its significance in development, organ size control, and cancer progression. Understanding TEAD2's functions is crucial for unraveling its contributions to normal physiological processes and disease states.
The recombinant Human TEAD2 was expressed with the amino acid range of 94-447. This TEAD2 protein is expected to have a theoretical molecular weight of 47.0 kDa. This protein is generated in a e.coli-based system. The TEAD2 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant TEAD2 protein in following stages of expression and purification.The human transcriptional enhancer factor TEF-4, also known as TEAD2, is a member of the TEAD family of transcription factors. TEAD2 plays a crucial role in the regulation of gene expression by binding to the MCAT element (Muscle CAT box), a common cis-regulatory element found in muscle-specific genes. TEAD2 is involved in various biological processes, including embryonic development, cell proliferation, and tissue homeostasis. It acts as a transcriptional coactivator and interacts with different transcription factors, such as Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), forming complexes that modulate gene expression. TEAD2’s involvement in the Hippo signaling pathway underscores its significance in development, organ size control, and cancer progression. Understanding TEAD2’s functions is crucial for unraveling its contributions to normal physiological processes and disease states.
| Cat.No | ACP02133 | Target Name | TEAD2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 94-447aa | Mol Weight | 47.0 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q15562 |
|---|
Uniprot Id
Q15562
Target Species
Human
Target Name
TEAD2
Target Full Name
Transcriptional enhancer factor TEF-4
Target Function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Target Subcellular Location
Nucleus.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Embryonic TEA domain containing factor; Etdf; ETEF 1; ETF; TEA domain family member 2; TEAD 2; TEAD-2; TEAD2; Tead2 protein (TEA domain family member 2 (Mapped), isoform CRA_b); TEAD2_HUMAN; TEF 4; TEF4; Transcriptional enhancer factor 4; Transcriptional enhancer factor TEF 4; Transcriptional enhancer factor TEF-4
Target Background
Enables several functions, including DNA-binding transcription factor activity; disordered domain specific binding activity; and transcription coactivator binding activity. Involved in hippo signaling; positive regulation of transcription, DNA-templated; and protein-containing complex assembly. Located in cytosol and nucleoplasm. Part of TEAD-YAP complex.
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