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Recombinant Human Transducin-like enhancer protein 6 (TLE6)

ACP11518

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Specifications

Cat.No	ACP11518	Target Name	TLE6
Target Synonyms	TLE6; Transducin-like enhancer protein 6	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-572
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9H808

Background Information

Uniprot Id

Q9H808
Target Species

Human
Target Name

TLE6
Target Full Name

Transducin-like enhancer protein 6
Target Function

Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4. Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation. Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression.; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning
Target Involvement

Preimplantation embryonic lethality 1 (PREMBL1)
Target Subcellular Location

Nucleus.; [Isoform 1]: Cytoplasm.; [Isoform 2]: Cytoplasm.
Target Protein Families

WD repeat Groucho/TLE family
Target Synonyms

TLE6; Transducin-like enhancer protein 6

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Recombinant Human Transducin-like enhancer protein 6 (TLE6)

Specifications

Immunogen Information

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