Recombinant Human Transient receptor potential cation channel subfamily M member 1 (TRPM1), Truncated

Uniprot Id

Q7Z4N2

Target Species

Human

Target Name

TRPM1

Target Full Name

Transient receptor potential cation channel subfamily M member 1

Target Function

Forms nonselective divalent cation-conducting channels which mediate the influx of Na(2+), Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization. Impermeable to zinc ions. In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions. Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel.

Target Involvement

Night blindness, congenital stationary, 1C (CSNB1C)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, axon.

Target Protein Families

Transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM1 sub-subfamily

Target Tissue Specificity

Expressed in the retina where it localizes to the outer plexiform layer. Specifically, it is expressed in retinal bipolar cells (BPCs) of the ON subtype. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but

Target Research Area

Signal Transduction

Target Synonyms

CSNB1C; Long transient receptor potential channel 1; LTrpC1; Melastatin 1; Melastatin-1; MLSN1; Transient receptor potential cation channel subfamily M member 1; Transient receptor potential cation channel, subfamily M, member 1; Transient receptor potential melastatin family; TRPM1; TRPM1 protein; TRPM1_HUMAN; Weakly similar to F54D1.5 [C.elegans]

Target Background

This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants.