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| Cat.No | ACP11465 | Target Name | EIF2B3 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-452 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NR50 |
|---|
Uniprot Id
Q9NR50
Target Species
Human
Target Name
EIF2B3
Target Full Name
Translation initiation factor eIF2B subunit gamma
Target Function
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Target Involvement
Leukodystrophy with vanishing white matter (VWM)
Target Protein Families
EIF-2B gamma/epsilon subunits family
Target Synonyms
EI2BG_HUMAN; EIF 2B; eIF 2B GDP GTP exchange factor subunit gamma ; eIF-2B GDP-GTP exchange factor subunit gamma; eIF2B-gamma; Eif2b3; EIF2Bgamma ; Eukaryotic translation initiation factor 2B subunit 3 gamma; Eukaryotic translation initiation factor 2B; gamma; eukaryotic translation initiation factor 2B; subunit 3 gamma; 58kDa; OTTHUMP00000010262; OTTHUMP00000010263; Translation initiation factor eIF-2B subunit gamma
Target Background
The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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