Home Products Recombinant Human Transmembrane prolyl 4-hydroxylase (P4HTM), Truncated

Recombinant Human Transmembrane prolyl 4-hydroxylase (P4HTM), Truncated

ACP04338

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Specifications

Cat.No	ACP04338	Target Name	P4HTM
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	82-563aa	Mol Weight	70.5kDa
Protein Length	Partial of Isoform 3	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9NXG6

Background Information

Uniprot Id

Q9NXG6
Target Species

Human
Target Name

P4HTM
Target Full Name

Transmembrane prolyl 4-hydroxylase
Target Function

Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Target Tissue Specificity

Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts.
Target Research Area

Cancer
Target Synonyms

EGLN4; HIF PH4; HIF Prolyl Hydroxylase 4; HIF prolyl hydroxylase PH 4; HIF prolyl hydroxylase PH4; HIF-PH4; HIF-prolyl hydroxylase 4; HIFPH4; HPH 4; HPH-4; Hypoxia inducible factor prolyl 4 hydroxylase; Hypoxia-inducible factor prolyl hydroxylase 4; P4H with transmembrane domain; P4H-TM; P4htm; P4HTM_HUMAN; PH 4; PH4; PHD 4; Proline 4 hydroxylase; prolyl 4-hydroxylase ; Transmembrane prolyl 4-hydroxylase

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Recombinant Human Transmembrane prolyl 4-hydroxylase (P4HTM), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Transmembrane prolyl 4-hydroxylase (P4HTM), Truncated Now

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