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| Cat.No | ACP15245 | Target Name | TMPRSS6 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IU80 |
|---|
Uniprot Id
Q8IU80
Target Species
Human
Target Name
TMPRSS6
Target Full Name
Transmembrane protease serine 6
Target Function
Membrane-bound serine protease. Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.
Target Involvement
Iron-refractory iron deficiency anemia (IRIDA)
Target Subcellular Location
Cell membrane; Single-pass type II membrane protein.
Target Protein Families
Peptidase S1 family
Target Synonyms
IRIDA; Matriptase-2; Membrane bound mosaic serine proteinase matriptase 2; Membrane type serine proteinase 2; MTSP 2; MTSP2; PVAE354; TMPRSS 6; TMPRSS6; TMPS6_HUMAN; TMSP 6; TMSP6; Transmembrane protease serine 6; Type II Membrane Serine Proteinase 6
Target Background
The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants.
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