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| Cat.No | ACP08546 | Target Name | TMEM106A |
|---|---|---|---|
| Target Synonyms | TMEM106A; Transmembrane protein 106A | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96A25 |
|---|
Uniprot Id
Q96A25
Target Species
Human
Target Name
TMEM106A
Target Full Name
Transmembrane protein 106A
Target Function
Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide. May play a role in inhibition of proliferation and migration.
Target Subcellular Location
Cell membrane; Single-pass membrane protein.
Target Protein Families
TMEM106 family
Target Tissue Specificity
Expressed in renal cells (at protein level). Expressed in epithelial cells.
Target Synonyms
TMEM106A; Transmembrane protein 106A
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