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Recombinant Human Transmembrane protein 106B (TMEM106B), Truncated

ACP19113

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Specifications

Cat.No	ACP19113	Target Name	TMEM106B
Target Synonyms	2310036D22Rik; 5830455K21Rik; 6430519M21Rik; AI428776; AI661344; FLJ11273; LRRGT00101; MGC33727; MGC94135; T106B_HUMAN; Tmem106b; Transmembrane protein 106B	Form	Liquid or Lyophilized powder
Expression System	Yeast	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9NUM4

Background Information

Uniprot Id

Q9NUM4
Target Species

Human
Target Name

TMEM106B
Target Full Name

Transmembrane protein 106B
Target Function

Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.
Target Involvement

Ubiquitin-positive frontotemporal dementia (UP-FTD); Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 (FTDALS1)
Target Subcellular Location

Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor.
Target Protein Families

TMEM106 family
Target Tissue Specificity

Expressed in frontal cortex.
Target Synonyms

2310036D22Rik; 5830455K21Rik; 6430519M21Rik; AI428776; AI661344; FLJ11273; LRRGT00101; MGC33727; MGC94135; T106B_HUMAN; Tmem106b; Transmembrane protein 106B
Target Background

Enables ATPase binding activity. Involved in dendrite morphogenesis and lysosome localization. Located in endosome and lysosomal membrane. Implicated in hypomyelinating leukodystrophy.

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Recombinant Human Transmembrane protein 106B (TMEM106B), Truncated

Specifications

Immunogen Information

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