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| Cat.No | ACP19568 | Target Name | TMEM108 |
|---|---|---|---|
| Target Synonyms | TMEM108; KIAA1690; RTLN; UNQ1875/PRO4318; Transmembrane protein 108; Retrolinkin | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6UXF1 |
|---|
Uniprot Id
Q6UXF1
Target Species
Human
Target Name
TMEM108
Target Full Name
Transmembrane protein 108
Target Function
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.
Target Subcellular Location
Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic density. Endosome membrane. Cell projection, axon. Cell projection, dendrite. Early endosome.
Target Synonyms
TMEM108; KIAA1690; RTLN; UNQ1875/PRO4318; Transmembrane protein 108; Retrolinkin
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