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| Cat.No | ACP08506 | Target Name | TMEM147 |
|---|---|---|---|
| Target Synonyms | TMEM147; Transmembrane protein 147; Protein NIFIE 14 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BVK8 |
|---|
Uniprot Id
Q9BVK8
Target Species
Human
Target Name
TMEM147
Target Full Name
BOS complex subunit TMEM147
Target Function
Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Together with SEC61 and TMCO1, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity. Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Target Synonyms
TMEM147; Transmembrane protein 147; Protein NIFIE 14
Target Background
Enables ribosome binding activity. Located in endoplasmic reticulum membrane. Part of protein-containing complex.
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