Recombinant Human Transmembrane protein 9 (TMEM9), Truncated

Uniprot Id

Q9P0T7

Target Species

Human

Target Name

TMEM9

Target Full Name

Proton-transporting V-type ATPase complex assembly regulator TMEM9

Target Function

Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking. By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation. TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC. In the liver, involved in hepatic regeneration.

Target Subcellular Location

Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein.

Target Protein Families

TMEM9 family

Target Tissue Specificity

Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expr

Target Synonyms

TMEM9; DERP4; TMEM9A; HSPC186; PSEC0012; UNQ631/PRO1248; Transmembrane protein 9; Dermal papilla-derived protein 4