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| Cat.No | ACP15467 | Target Name | TICRR |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q7Z2Z1 |
|---|
Uniprot Id
Q7Z2Z1
Target Species
Human
Target Name
TICRR
Target Full Name
Treslin
Target Function
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
Target Subcellular Location
Nucleus. Note=Associates with chromatin.
Target Protein Families
Treslin family
Target Synonyms
C15orf42; chromosome 15 open reading frame 42 ; replication-stimulating protein; SLD3; SLD3 homolog; SLD3; yeast ; homolog of; TICRR; TICRR_HUMAN; TopBP1-interacting; TopBP1-interacting checkpoint and replication regulator; Treslin
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