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| Cat.No | ACP18706 | Target Name | TRDN |
|---|---|---|---|
| Target Synonyms | dJ166D18.1; DKFZp779I2253; MGC88285; OTTHUMP00000040354; TDN; TRDN; TRDN_HUMAN; Triadin; TRISK 51; TRISK; TRISK51 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q13061 |
|---|
Uniprot Id
Q13061
Target Species
Human
Target Name
TRDN
Target Full Name
Triadin
Target Function
Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Target Involvement
Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness (CPVT5)
Target Subcellular Location
Cell membrane. Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.
Target Synonyms
dJ166D18.1; DKFZp779I2253; MGC88285; OTTHUMP00000040354; TDN; TRDN; TRDN_HUMAN; Triadin; TRISK 51; TRISK; TRISK51
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