Recombinant Human Tribbles homolog 1 (TRIB1)

Uniprot Id

Q96RU8

Target Species

Human

Target Name

TRIB1

Target Full Name

Tribbles homolog 1

Target Function

Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner. Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain. Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity.

Target Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, Tribbles subfamily

Target Tissue Specificity

Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.

Target Synonyms

C8FW; G-protein-coupled receptor-induced gene 2 protein; GIG-2; GIG2; SKIP1; TRB-1; TRB1; Trib1; TRIB1_HUMAN; Tribbles homolog 1

Target Background

Enables mitogen-activated protein kinase kinase binding activity and protein kinase inhibitor activity. Involved in several processes, including JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; and regulation of protein kinase activity. Located in cytoplasm and nucleus.