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| Cat.No | ACP11656 | Target Name | TRIM10 |
|---|---|---|---|
| Target Synonyms | TRIM10; RFB30; RNF9; Tripartite motif-containing protein 10; B30-RING finger protein; RING finger protein 9 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-481 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UDY6 |
|---|
Uniprot Id
Q9UDY6
Target Species
Human
Target Name
TRIM10
Target Full Name
Tripartite motif-containing protein 10
Target Function
E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling. In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1.
Target Subcellular Location
Cytoplasm.
Target Protein Families
TRIM/RBCC family
Target Synonyms
TRIM10; RFB30; RNF9; Tripartite motif-containing protein 10; B30-RING finger protein; RING finger protein 9
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