Home Products Recombinant Human Tripartite motif-containing protein 2 (TRIM2), Truncated

Recombinant Human Tripartite motif-containing protein 2 (TRIM2), Truncated

ACP12303

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Specifications

Cat.No	ACP12303	Target Name	TRIM2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9C040

Background Information

Uniprot Id

Q9C040
Target Species

Human
Target Name

TRIM2
Target Full Name

Tripartite motif-containing protein 2
Target Function

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
Target Involvement

Charcot-Marie-Tooth disease 2R (CMT2R)
Target Subcellular Location

Cytoplasm.
Target Protein Families

TRIM/RBCC family
Target Synonyms

E3 ubiquitin protein ligase TRIM2; KIAA0517; RING finger protein 86; RNF86; Trim2; TRIM2_HUMAN; Tripartite motif containing 2; Tripartite motif protein 2; Tripartite motif protein TRIM2; Tripartite motif-containing 2; Tripartite motif-containing protein 2
Target Background

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants.

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Recombinant Human Tripartite motif-containing protein 2 (TRIM2), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Tripartite motif-containing protein 2 (TRIM2), Truncated Now

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