Recombinant Human Tripartite motif-containing protein 26 (TRIM26)

Uniprot Id

Q12899

Target Species

Human

Target Name

TRIM26

Target Full Name

Tripartite motif-containing protein 26

Target Function

E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

TRIM/RBCC family

Target Synonyms

Acid finger protein; AFP; CAM25547; RING finger protein 95; RNF95; TRI26_HUMAN; TRIM26; tripartite motif containing 26 ; Tripartite motif-containing protein 26; widely expressed acid zinc finger protein ; Zinc finger protein 173; Zinc finger protein 173; formerly; ZNF173; ZNF173; formerly

Target Background

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene.