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| Cat.No | ACP15800 | Target Name | TRIM40 |
|---|---|---|---|
| Target Synonyms | TRIM40; RNF35; Tripartite motif-containing protein 40; Probable E3 NEDD8-protein ligase; RING finger protein 35 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-258 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6P9F5 |
|---|
Uniprot Id
Q6P9F5
Target Species
Human
Target Name
TRIM40
Target Full Name
E3 ubiquitin ligase TRIM40
Target Function
E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating DDX58 and IFIH1 receptors, leading to their proteasomal degradation. Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation.
Target Protein Families
TRIM/RBCC family
Target Tissue Specificity
Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract.
Target Synonyms
TRIM40; RNF35; Tripartite motif-containing protein 40; Probable E3 NEDD8-protein ligase; RING finger protein 35
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