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| Cat.No | ACP12148 | Target Name | TRIM6 |
|---|---|---|---|
| Target Synonyms | TRIM6; RNF89; Tripartite motif-containing protein 6; EC 2.3.2.27; RING finger protein 89; RING-type E3 ubiquitin transferase TRIM6 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-488 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9C030 |
|---|
Uniprot Id
Q9C030
Target Species
Human
Target Name
TRIM6
Target Full Name
Tripartite motif-containing protein 6
Target Function
E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway. In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response. Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells.
Target Subcellular Location
Cytoplasm.
Target Protein Families
TRIM/RBCC family
Target Synonyms
TRIM6; RNF89; Tripartite motif-containing protein 6; EC 2.3.2.27; RING finger protein 89; RING-type E3 ubiquitin transferase TRIM6
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