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| Cat.No | ACP11580 | Target Name | TRIM7 |
|---|---|---|---|
| Target Synonyms | Glycogenin-interacting protein; GNIP; RING finger protein 90; RNF90; TRIM7; TRIM7_HUMAN; Tripartite Motif Containing 7; Tripartite motif protein TRIM 7; Tripartite motif-containing protein 7 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-511 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9C029 |
|---|
Uniprot Id
Q9C029
Target Species
Human
Target Name
TRIM7
Target Full Name
E3 ubiquitin-protein ligase TRIM7
Target Function
E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation. Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon. Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation.; (Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination
Target Subcellular Location
Cytoplasm. Golgi apparatus.
Target Protein Families
TRIM/RBCC family
Target Tissue Specificity
Skeletal muscle and placenta, at lower levels in heart, brain and pancreas. Isoform 1 is widely expressed with high level in testis, kidney and heart.
Target Synonyms
Glycogenin-interacting protein; GNIP; RING finger protein 90; RNF90; TRIM7; TRIM7_HUMAN; Tripartite Motif Containing 7; Tripartite motif protein TRIM 7; Tripartite motif-containing protein 7
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