Recombinant Human Trypsin-2 (PRSS2)

Uniprot Id

P07478

Target Species

Human

Target Name

PRSS2

Target Full Name

Trypsin-2

Target Function

In the ileum, may be involved in defensin processing, including DEFA5.

Target Subcellular Location

Secreted, extracellular space.

Target Protein Families

Peptidase S1 family

Target Tissue Specificity

Expressed in Paneth cells, at the base of small intestinal crypts.

Target Research Area

Cell Biology

Target Synonyms

(Anionic trypsinogen)(Serine protease 2)(Trypsin II)

Target Background

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.