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Our top-quality Recombinant Human WARS protein is a crucial research tool for scientists working in the area of Epigenetics and Nuclear Signaling. This full-length mature protein, expressed in the E.coli system, covers the 2-471aa region of Tryptophan--tRNA ligase, cytoplasmic (Interferon-induced protein 53). For added convenience in protein purification and detection, our WARS protein features both an N-terminal 10xHis-tag and a C-terminal Myc-tag, ensuring a consistently high standard for your experiments. With a purity greater than 85% as determined by SDS-PAGE, our Recombinant Human WARS protein is available in both liquid and lyophilized powder forms. Trust this exceptional protein to support your Epigenetics and Nuclear Signaling research, delivering consistent and outstanding results.
Our top-quality Recombinant Human WARS protein is a crucial research tool for scientists working in the area of Epigenetics and Nuclear Signaling. This full-length mature protein, expressed in the E.coli system, covers the 2-471aa region of Tryptophan–tRNA ligase, cytoplasmic (Interferon-induced protein 53). For added convenience in protein purification and detection, our WARS protein features both an N-terminal 10xHis-tag and a C-terminal Myc-tag, ensuring a consistently high standard for your experiments.
With a purity greater than 85% as determined by SDS-PAGE, our Recombinant Human WARS protein is available in both liquid and lyophilized powder forms. Trust this exceptional protein to support your Epigenetics and Nuclear Signaling research, delivering consistent and outstanding results.
| Cat.No | ACP02307 | Target Name | WARS |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-471aa | Mol Weight | 60.0 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P23381 |
|---|
Uniprot Id
P23381
Target Species
Human
Target Name
WARS
Target Full Name
Tryptophan--tRNA ligase, cytoplasmic
Target Function
Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Class-I aminoacyl-tRNA synthetase family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Gamma 2; GAMMA-2; Gamma2; hWRS; IFI 53; IFI53; IFP 53; IFP53; Interferon induced protein 53; Interferon-induced protein 53; SYWC_HUMAN; T2-TrpRS; TrpRS; Tryptophan tRNA ligase; cytoplasmic; Tryptophan tRNA ligase 1 cytoplasmic; Tryptophan tRNA ligase; Tryptophan--tRNA ligase; Tryptophanyl tRNA synthetase ; Tryptophanyl tRNA synthetase cytoplasmic; WARS; WARS protein; WRS
Target Background
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene.
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