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| Cat.No | ACP15746 | Target Name | TTLL7 |
|---|---|---|---|
| Target Synonyms | RP5-836J3.2; Testis development protein NYD-SP30; Ttll7; TTLL7_HUMAN; Tubulin polyglutamylase TTLL7; Tubulin tyrosine ligase like family member 7; Tubulin--tyrosine ligase-like protein 7 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6ZT98 |
|---|
Uniprot Id
Q6ZT98
Target Species
Human
Target Name
TTLL7
Target Full Name
Tubulin polyglutamylase TTLL7
Target Function
Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Mediates both ATP-dependent initiation and elongation steps of the polyglutamylation reaction. Preferentially modifies the beta-tubulin tail over an alpha-tail. Competes with monoglycylase TTLL3 for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions. Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation.
Target Subcellular Location
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, dendrite. Perikaryon.
Target Protein Families
Tubulin--tyrosine ligase family
Target Tissue Specificity
Highly expressed in the nervous system including spinal cord, thalamus, hippocampus, hypothalamus and cerebellum.
Target Synonyms
RP5-836J3.2; Testis development protein NYD-SP30; Ttll7; TTLL7_HUMAN; Tubulin polyglutamylase TTLL7; Tubulin tyrosine ligase like family member 7; Tubulin--tyrosine ligase-like protein 7
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