Recombinant Human Tubulin-specific chaperone A (TBCA)

Uniprot Id

O75347

Target Species

Human

Target Name

TBCA

Target Full Name

Tubulin-specific chaperone A

Target Function

Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

Target Subcellular Location

Cytoplasm, cytoskeleton.

Target Protein Families

TBCA family

Target Synonyms

CFA; Chaperonin cofactor A; Co chaperonin associated with a & b tubulin; Cofactor A; tbca; TBCA_HUMAN; TCP1 chaperonin cofactor A; TCP1-chaperonin cofactor A; Tubulin cofactor a; Tubulin folding cofactor A; Tubulin specific chaperone a; Tubulin-folding cofactor A; Tubulin-specific chaperone A

Target Background

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.