Recombinant human Tubulin-specific chaperone C

Uniprot Id

Q15814

Target Species

Human

Target Name

TBCC

Target Full Name

Tubulin-specific chaperone C

Target Function

Tubulin-folding protein; involved in the final step of the tubulin folding pathway.

Target Subcellular Location

Cytoplasm. Note=Detected predominantly in the photoreceptor connecting cilium.

Target Protein Families

TBCC family

Target Tissue Specificity

Expressed in the retina. Expressed in the rod and cone photoreceptors, extending from the inner segments (IS), through the outer nuclear layer (ONL) and into the synapses in the outer plexiform layer (OPL). Strongly expressed to the photoreceptor connecti

Target Research Area

Signal Transduction

Target Synonyms

Beta tubulin cofactor C; CFC; TBCC; TBCC_HUMAN; Tubulin folding cofactor C; Tubulin specific chaperone c; Tubulin-folding cofactor C; Tubulin-specific chaperone C

Target Background

Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.