Recombinant Human Tubulin-specific chaperone E (TBCE)

Uniprot Id

Q15813

Target Species

Human

Target Name

TBCE

Target Full Name

Tubulin-specific chaperone E

Target Function

Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.

Target Involvement

Hypoparathyroidism-retardation-dysmorphism syndrome (HRDS); Kenny-Caffey syndrome 1 (KCS1); Encephalopathy, progressive, with amyotrophy and optic atrophy (PEAMO)

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton.

Target Protein Families

TBCE family

Target Synonyms

HRD; KCS; KCS1; Pac2; tbce; TBCE_HUMAN; Tubulin specific chaperone e; Tubulin-folding cofactor E; Tubulin-specific chaperone E

Target Background

Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene.